This, in turn, increases GABAergic activity. By binding to this site, F-Phenibut may reduce the release of several excitatory neurotransmitters, including glutamate, substance P, acetylcholine, and norepinephrine. It is also possible that F-Phenibut binds to the α2δ-1 site of voltage-gated calcium channels in a manner similar to that of other gabapentinoids. Additionally, the widely prescribed gabapentinoid pregabalin also possesses a similar structure as phenibut, except that the phenyl group is instead replaced with an isobutyl group in the S configuration.į-phenibut acts as a potent agonist of the GABA-B receptor and in this regard is more similar to baclofen than phenibut. It has an almost identical chemical structure to baclofen (only replacing a chlorine with a fluorine atom in the para-position of the phenyl group). It is a chiral molecule and thus has two potential configurations as (R)- and (S)-enantiomers. Īs with phenibut, F-Phenibut is a derivative of GABA, except with a fluorine-substituted phenyl group in the β-position of the molecule. It is a derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid ( GABA), with an addition of a phenyl ring that allows it to cross the blood–brain barrier. The substance can be classified as a gabapentinoid, a class which contains other substances such as gabapentin, pregabalin, baclofen, and GABOB. It has recently become available through online research chemical vendors, although little is known about this substance, particularly its potential toxicity and addiction potential. F-Phenibut possesses an effect profile similar to phenibut but with a faster onset, significantly increased potency, and shorter total duration. It is not a recommendation and should be verified with other sources for accuracy.į-Phenibut (also known as 4-Fluorophenibut, Fluorophenibut, Fluorobut, Baflofen and CGP-11130) is a central nervous system depressant and closely related structural analog of phenibut. See responsible use section.ĭISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. 5-amino-4-(4-fluorophenyl)-1-hydroxypentan-2-one
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. Archives
June 2023
Categories |